New research indicates that people who discontinue blockbuster weight-loss injections like Wegovy and Mounjaro can put back on lost weight far faster than those who halt conventional lifestyle programs.
Findings released in a leading medical journal demonstrates that while obese people frequently drop substantial amounts of their body weight while using the jabs, the weight is regained at an estimated rate of nearly a kilo each month upon discontinuation.
"People using these medications should be aware of the danger of fast rebound weight gain when the therapy is stopped," stated expert Dr. Susan Jebb.
Such speed of recovery means a return to pre-treatment mass within about a year and a half.
Comparing Treatments
The research, which examined 37 of trials involving over 9,000 of patients, contrasted the results of the injectable medications with older methods.
Researchers note that people who shed pounds through diet and exercise generally experience a less rapid creep back—perhaps 0.1 kg a month—after stopping.
Explaining the Quick Regain
Experts believe the mechanism of the injections explains the accelerated rebound.
The injections copy a natural hormone called glucagon-like peptide-1, which helps regulate hunger.
"Sustained high doses of GLP-1 levels several times higher than normal could lead to the body to generate a reduced amount of its endogenous GLP-1, and could diminish sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication results in appetite is no longer kept in check, making overeating much more probable."
A Lifelong Disease?
Medical guidelines suggest the injections for people with weight-linked health risks, alongside recommended diet and exercise modifications.
Professionals argue that, due to the significant potential of relapse, the treatment is often life-long.
This perspective is echoed by pharmaceutical companies, who say that the results "highlight the persistent character of obesity," akin to managing conditions like hypertension.
Patient Experiences
People who have come off the medication report a intense return of hunger.
"It was like something activating and I was suddenly ravenous," described an individual.
This difficulty is compounded if individuals have not established permanent dietary or behavioural changes during treatment.
Growing Interest
Recent estimates suggest that millions of people in the UK have used weight-loss jabs in the last 12 months, with demand continuing to grow.
- Adoption is more common among females compared to males.
- The 40s and 50s age group shows the highest usage rates.
- Many obtain the drugs through private healthcare rather than public health services.
In conclusion, clinicians emphasize that while these medications are powerful agents for shedding pounds, they are not a magic solution and long-term success likely depends on ongoing behavioural changes.
